PT  - JOURNAL ARTICLE
AU  - Michael-John Dolan
AU  - Ghislain Belliart-Guérin
AU  - Alexander Shakeel Bates
AU  - Yoshinori Aso
AU  - Shahar Frechter
AU  - Ruairí J.V. Roberts
AU  - Philipp Schlegel
AU  - Allan Wong
AU  - Adnan Hammad
AU  - Davi Bock
AU  - Gerald M. Rubin
AU  - Thomas Preat
AU  - Pierre-Yves Plaçais
AU  - Gregory S.X.E. Jefferis
TI  - Communication from learned to innate olfactory processing centers is required for memory retrieval in <em>Drosophila</em>
AID  - 10.1101/167312
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 167312
4099  - http://biorxiv.org/content/early/2017/08/29/167312.short
4100  - http://biorxiv.org/content/early/2017/08/29/167312.full
AB  - Animals can show either learned or innate behavioral responses to a given stimulus. How these circuits interact to produce an appropriate behavioral response is unknown. In the Drosophila olfactory system, the lateral horn (LH) and the mushroom body (MB) are thought to mediate innate and learned olfactory behavior respectively, although the function of the LH has not been directly tested. Here we identify two LH cell-types (PD2a1/b1) that receive input from an MB output neuron required for recall of aversive olfactory memories. In contrast to the model above we find that PD2a1/b1 are required for aversive memory retrieval. PD2a1/b1 activity is modulated by training, indicating that memory information is passed to the innate olfactory processing centre. We map the connectivity of PD2a1/b1 to other olfactory neurons with connectomic data. This provides a circuit mechanism by which learned and unlearned olfactory information can interact to produce appropriate behavior.