PT  - JOURNAL ARTICLE
AU  - Benito, Eva
AU  - Kerimoglu, Cemil
AU  - Ramachandran, Binu
AU  - Zhou, Qihui
AU  - Pena, Tonatiuh
AU  - Capece, Vincenzo
AU  - Jain, Gaurav
AU  - Burkhardt, Susanne
AU  - Stilling, Roman
AU  - Edbauer, Dieter
AU  - Dean, Camin
AU  - Fischer, André
TI  - RNA-dependent intergenerational inheritance of enhanced synaptic plasticity after environmental enrichment
AID  - 10.1101/178814
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 178814
4099  - http://biorxiv.org/content/early/2017/08/31/178814.short
4100  - http://biorxiv.org/content/early/2017/08/31/178814.full
AB  - Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning & memory and lower the risk for various complex diseases including Alzheimer’s disease. Here we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that the effect is mediated through sperm RNA and is explained by microRNAs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific microRNAs as candidates mechanistically involved in this type of transmission.