RT Journal Article
SR Electronic
T1 Systemic evidence of acute seizure-associated neuronal injury in patients with temporal lobe epilepsy
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 184366
DO 10.1101/184366
A1 Shailaja Kunda
A1 Reghann G LaFrance-Corey
A1 Fatemeh Khadjevand
A1 Gregory A Worrell
A1 Charles L Howe
YR 2017
UL http://biorxiv.org/content/early/2017/09/04/184366.abstract
AB Patients with drug refractory temporal lobe epilepsy frequently accumulate cognitive impairment over time, suggesting neuronal loss induced by seizures. We measured serum levels of neuron-specific enolase (NSE), a neuronal injury marker, relative to levels of S100β, a marker of glial injury, at 6 AM, 9 AM, noon, 3 PM, and 6 PM over the course of several days in 7 epilepsy patients and 4 healthy controls. All epilepsy patients exhibited significant deviations in NSE levels through time, and 4 of the epilepsy patients exhibited large sample entropy values and large signal variation metrics for NSE relative to S100β. Controls did not exhibit such changes. Correlation analysis revealed that NSE levels were significantly elevated after clinical seizure events. There was also a highly significant relationship between increased EEG spike frequency and an increase in serum NSE levels measured 24 hours later. The detection of large but transient post-ictal increases in NSE suggests that even self-limited seizures may cause an injury to neurons that underlies cognitive decline in some patients. Post-ictal assessment of serum NSE may serve as a biomarker for measuring the efficacy of future acute neuroprotective strategies in epilepsy patients.