TY - JOUR T1 - High angular resolution diffusion MRI reveals conserved and deviant programs in the paths that guide human cortical circuitry JF - bioRxiv DO - 10.1101/576967 SP - 576967 AU - Christine J. Charvet AU - Avilash Das AU - Jae W. Song AU - Deselyn J. Tindal-Burgess AU - Priya Kabaria AU - Guangping Dai AU - Tara Kane AU - Emi Takahashi Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/04/09/576967.abstract N2 - Diffusion MR tractography represents a novel opportunity to investigate conserved and deviant developmental programs between humans and other species such as mice. To that end, we acquired high angular resolution diffusion MR scans of mice (embryonic day [E] 10.5 to post-natal week [PW] 4) and human brains (gestational week [GW] 17 to 30) at successive stages of fetal development to investigate potential evolutionary changes in radial organization and emerging pathways between humans and mice. We compare radial glial development as well as commissural development (e.g., corpus callosum), primarily because our findings can be integrated with previous work. We also compare corpus callosal growth trajectories across primates (i.e., humans, rhesus macaques) and rodents (i.e., mice). One major finding is that the developing cortex of humans is predominated by pathways likely associated with a radial glial organization at GW 17-20, which is not as evident in age-matched mice (E 16.5, 17.5). Another finding is that, early in development, the corpus callosum follows a similar developmental timetable in primates (i.e., macaques, humans) as in mice. However, the corpus callosum grows for an extended period of time in primates compared with rodents. Taken together, these findings highlight deviant developmental programs underlying the emergence of cortical pathways in the human brain. ER -