PT  - JOURNAL ARTICLE
AU  - Graham L. Baum
AU  - David R. Roalf
AU  - Philip A. Cook
AU  - Rastko Ciric
AU  - Adon F.G. Rosen
AU  - Cedric Xia
AU  - Mark A. Elliot
AU  - Kosha Ruparel
AU  - Ragini Verma
AU  - Birkan Tunc
AU  - Ruben C. Gur
AU  - Raquel E. Gur
AU  - Danielle S. Bassett
AU  - Theodore D. Satterthwaite
TI  - The Impact of In-Scanner Head Motion on Structural Connectivity Derived from Diffusion Tensor Imaging
AID  - 10.1101/185397
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 185397
4099  - http://biorxiv.org/content/early/2017/09/07/185397.short
4100  - http://biorxiv.org/content/early/2017/09/07/185397.full
AB  - Multiple studies have shown that data quality is a critical confound in the construction of brain networks derived from functional MRI. This problem is particularly relevant for studies of human brain development where important variables (such as participant age) are correlated with data quality. Nevertheless, the impact of head motion on estimates of structural connectivity derived from diffusion tractography methods remains poorly characterized. Here, we evaluated the impact of in-scanner head motion on structural connectivity using a sample of 949 participants (ages 8-23 years old) who passed a rigorous quality assessment protocol for diffusion tensor imaging (DTI) acquired as part of the Philadelphia Neurodevelopmental Cohort. Structural brain networks were constructed for each participant using both deterministic and probabilistic tractography. We hypothesized that subtle variation in head motion would systematically bias estimates of structural connectivity and confound developmental inference, as observed in previous studies of functional connectivity. Even following quality assurance and retrospective correction for head motion, eddy currents, and field distortions, in-scanner head motion significantly impacted the strength of structural connectivity in a consistency-and length-dependent manner. Specifically, increased head motion was associated with reduced estimates of structural connectivity for high-consistency network edges, which included both short-and long-range connections. In contrast, motion inflated estimates of structural connectivity for low-consistency network edges that were primarily shorter-range. Finally, we demonstrate that age-related differences in head motion can both inflate and obscure developmental inferences on structural connectivity. Taken together, these data delineate the systematic impact of head motion on structural connectivity, and provide a critical context for identifying motion-related confounds in studies of structural brain network development.