RT Journal Article SR Electronic T1 A novel data-driven model for real-time influenza forecasting JF bioRxiv FD Cold Spring Harbor Laboratory SP 185512 DO 10.1101/185512 A1 Siva R. Venna A1 Amirhossein Tavanaei A1 Raju N. Gottumukkala A1 Vijay V. Raghavan A1 Anthony Maida A1 Stephen Nichols YR 2017 UL http://biorxiv.org/content/early/2017/09/08/185512.abstract AB We provide data-driven machine learning methods that are capable of making real-time influenza forecasts that integrate the impacts of climatic factors and geographical proximity to achieve better forecasting performance. The key contributions of our approach are both applying deep learning methods and incorporation of environmental and spatio-temporal factors to improve the performance of the influenza forecasting models. We evaluate the method on Influenza Like Illness (ILI) counts and climatic data, both publicly available data sets. Our proposed method outperforms existing known influenza forecasting methods in terms of their Mean Absolute Percentage Error and Root Mean Square Error. The key advantages of the proposed data-driven methods are as following: (1) The deep-learning model was able to effectively capture the temporal dynamics of flu spread in different geographical regions, (2) The extensions to the deep-learning model capture the influence of external variables that include the geographical proximity and climatic variables such as humidity, temperature, precipitation and sun exposure in future stages, (3) The model consistently performs well for both the city scale and the regional scale on the Google Flu Trends (GFT) and Center for Disease Control (CDC) flu counts. The results offer a promising direction in terms of both data-driven forecasting methods and capturing the influence of spatio-temporal and environmental factors for influenza forecasting methods.