PT  - JOURNAL ARTICLE
AU  - Alireza Yazdani
AU  - He Li
AU  - Matthew R. Bersi
AU  - Paolo Di Achille
AU  - Joseph Insley
AU  - Jay D. Humphrey
AU  - George Em Karniadakis
TI  - Data-driven Modeling of Thrombus Size and Shape in Aortic Dissections: Role of Hemodynamics
AID  - 10.1101/187914
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 187914
4099  - http://biorxiv.org/content/early/2017/09/12/187914.short
4100  - http://biorxiv.org/content/early/2017/09/12/187914.full
AB  - Aortic dissection is a pathology that manifests due to micro-structural defects in the aortic wall. Blood enters the damaged wall through an intimal tear, thereby creating a so-called false lumen and exposing the blood to thrombogenic intramural constituents such as collagen. The natural history of this acute vascular injury thus depends, in part, on thrombus formation, maturation, and possible healing within the false lumen. A key question is: Why do some false lumens thrombose completely while other thrombose partially or little at all? An ability to predict the location and extent of thrombus in subjects with dissection could contribute significantly to clinical decision-making, including interventional design. We develop, for the first time, a data-driven particle-continuum model for thrombus formation in a murine model of aortic dissection. In the proposed model, we simulate a final-value problem in lieu of the original initial-value problem with significantly fewer particles that may grow in size upon activation, representing the local concentration of blood-borne species. Numerical results confirm that geometry and local hemodynamics play significant roles in the acute progression of thrombus. Despite geometrical differences between murine and human dissections, mouse models can provide considerable insight and have gained in popularity owing to their reproducibility. Our results for three classes of geometrically different false lumens show that thrombus forms and extends to a greater extent in regions with lower bulk shear rates. Dense thrombi are less likely to form in high-shear zones and in the presence of strong vortices. The present data-driven study suggests that the proposed model is robust and can be employed to assess thrombus formation in human aortic dissections.