PT - JOURNAL ARTICLE AU - Julian Hecker AU - Ingo Ruczinski AU - Brent Coull AU - Christoph Lange TI - An almost nearly optimal sequential testing approach to permutation-based association testing AID - 10.1101/186361 DP - 2017 Jan 01 TA - bioRxiv PG - 186361 4099 - http://biorxiv.org/content/early/2017/09/12/186361.short 4100 - http://biorxiv.org/content/early/2017/09/12/186361.full AB - The following technical report describes the technical details for the implementation of a sequential testing approach to permutation-based association testing in whole-genome sequencing studies. The sequential testing approach enables to control the probability of a type 1 and type 2 error at arbitrary small pre-specified levels and approaches the theoretical minimum of expected number of required permutations as these levels go to zero.