PT  - JOURNAL ARTICLE
AU  - Mohanraj Krishnan
AU  - Tanya J Major
AU  - Ruth K Topless
AU  - Ofa Dewes
AU  - Lennex Yu
AU  - John MD Thompson
AU  - Lesley McCowan
AU  - Janak de Zoysa
AU  - Lisa K Stamp
AU  - Nicola Dalbeth
AU  - Jennie Harré Hindmarsh
AU  - Nuku Rapana
AU  - Ranjan Deka
AU  - Winston W H Eng
AU  - Daniel E Weeks
AU  - Ryan L Minster
AU  - Stephen T McGarvey
AU  - Satupa’itea Viali
AU  - Phillip Wilcox
AU  - David Grattan
AU  - Peter R Shepherd
AU  - Andrew N Shelling
AU  - Rinki Murphy
AU  - Tony R Merriman
TI  - Discordant association of the <em>CREBRF rs373863828</em> minor allele with increased body mass index and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living i Aotearoa New Zealandar
AID  - 10.1101/188110
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 188110
4099  - http://biorxiv.org/content/early/2017/09/13/188110.short
4100  - http://biorxiv.org/content/early/2017/09/13/188110.full
AB  - The minor allele of CREBRF rs373863828 associates with increased body mass index (BMI) and reduced risk of type 2 diabetes (T2D) in the Samoan population of Samoa and American Samoa. Our aim was to test rs373863828 for association with BMI and odds of T2D, gout and chronic kidney disease (CKD) in Māori and Pacific (Polynesian) people living in Aotearoa New Zealand in 2,286 adults. Association analyses were performed by linear and logistic regression with BMI, log-transformed BMI, waist circumference, T2D, gout, CKD, and serum and urate lipid measures. Analyses were adjusted for age, sex, the first four genome-wide principal components, and (when appropriate) BMI and T2D. For the minor allele of rs373863828 the effect size for log-transformed BMI was 0.038 (P=4.8x10-6) and for T2D was OR=0.59 (P=1.9x10-6). The minor allele conferreda dominant effect for both BMI and T2D. Although there was weak evidence for association with increased urate (P=0.026), there was no evidence for association with gout (P=0.98) or CKD (P=0.59). Our results replicated, with very similar effect sizes, association of the minor allele of rs373863828 with higher BMI but lower odds of T2D among New Zealand Polynesian adults as in Samoan adults living in Samoa and American Samoa.