RT Journal Article
SR Electronic
T1 Comparison of GWAS models to identify non-additive genetic control of flowering time in sunflower hybrids
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 188235
DO 10.1101/188235
A1 Fanny Bonnafous
A1 Ghislain Fievet
A1 Nicolas Blanchet
A1 Marie-Claude Boniface
A1 Sébastien Carrère
A1 Jérôme Gouzy
A1 Ludovic Legrand
A1 Gwenola Marage
A1 Emmanuelle Bret-Mestries
A1 Stéphane Munos
A1 Nicolas Pouilly
A1 Patrick Vincourt
A1 Nicolas Langlade
A1 Brigitte Mangin
YR 2017
UL http://biorxiv.org/content/early/2017/09/13/188235.abstract
AB Genome-wide association studies are a powerful and widely used tool to decipher the genetic control of complex traits. One of the main challenges for hybrid crops, such as maize or sunflower, is to model the hybrid vigor in the linear mixed models, considering the relatedness between individuals. Here, we compared two additive and three non-additive association models for their ability to identify genomic regions associated with flowering time in sunflower hybrids. A panel of 452 sunflower hybrids, corresponding to incomplete crossing between 36 male lines and 36 female lines, was phenotyped in five environments and genotyped for 2,204,423 SNPs. Intra-locus effects were estimated in multi-locus models to detect genomic regions associated with flowering time using the different models. Thirteen quantitative trait loci were identified in total, two with both model categories and one with only non-additive models. A quantitative trait loci on LG09, detected by both the additive and non-additive models, is located near a GAI homolog and is presented in detail. Overall, this study shows the added value of non-additive modeling of allelic effects for identifying genomic regions that control traits of interest and that could participate in the heterosis observed in hybrids.