RT Journal Article SR Electronic T1 Chromatin interactions correlate with local transcriptional activity in Saccharomyces cerevisiae JF bioRxiv FD Cold Spring Harbor Laboratory SP 021725 DO 10.1101/021725 A1 Zackary Scholl A1 Jianling Zhong A1 Alexander J. Hartemink YR 2015 UL http://biorxiv.org/content/early/2015/06/30/021725.abstract AB Genome organization is crucial for efficiently responding to DNA damage and regulating transcription. In this study, we relate the genome organization of Saccharomyces cerevisiae (budding yeast) to its transcription activity by analyzing published circularized chromosome conformation capture (4C) data in conjunction with eight separate datasets describing genome-wide transcription rate or RNA polymerase II (Pol II) occupancy. We find that large chromosome segments are more likely to interact in areas that have high transcription rate or Pol II occupancy. Additionally, we find that groups of genes with similar transcription rates or similar Pol II occupancy are more likely to have higher numbers of chromosomal interactions than groups of random genes. We hypothesize that transcription localization occurs around sets of genes with similar transcription rates, and more often around genes that are highly transcribed, in order to produce more efficient transcription. Our analysis cannot discern whether gene co-localization occurs because of similar transcription rates or whether similar transcription rates are a consequence of co-localization.