PT - JOURNAL ARTICLE AU - Mathieson, Iain AU - Roodenberg, Songül Alpaslan AU - Posth, Cosimo AU - Szécsényi-Nagy, Anna AU - Rohland, Nadin AU - Mallick, Swapan AU - Olalde, Iñigo AU - Broomandkhoshbacht, Nasreen AU - Candilio, Francesca AU - Cheronet, Olivia AU - Fernandes, Daniel AU - Ferry, Matthew AU - Gamarra, Beatriz AU - Fortes, Gloria González AU - Haak, Wolfgang AU - Harney, Eadaoin AU - Jones, Eppie AU - Keating, Denise AU - Krause-Kyora, Ben AU - Kucukkalipci, Isil AU - Michel, Megan AU - Mittnik, Alissa AU - Nägele, Kathrin AU - Novak, Mario AU - Oppenheimer, Jonas AU - Patterson, Nick AU - Pfrengle, Saskia AU - Sirak, Kendra AU - Stewardson, Kristin AU - Vai, Stefania AU - Alexandrov, Stefan AU - Alt, Kurt W. AU - Andreescu, Radian AU - Antonović, Dragana AU - Ash, Abigail AU - Atanassova, Nadezhda AU - Bacvarov, Krum AU - Gusztáv, Mende Balázs AU - Bocherens, Hervé AU - Bolus, Michael AU - Boroneanţ, Adina AU - Boyadzhiev, Yavor AU - Budnik, Alicja AU - Burmaz, Josip AU - Chohadzhiev, Stefan AU - Conard, Nicholas J. AU - Cottiaux, Richard AU - Čuka, Maja AU - Cupillard, Christophe AU - Drucker, Dorothée G. AU - Elenski, Nedko AU - Francken, Michael AU - Galabova, Borislava AU - Ganetovski, Georgi AU - Gély, Bernard AU - Hajdu, Tamás AU - Handzhyiska, Veneta AU - Harvati, Katerina AU - Higham, Thomas AU - Iliev, Stanislav AU - Janković, Ivor AU - Karavanić, Ivor AU - Kennett, Douglas J. AU - Komšo, Darko AU - Kozak, Alexandra AU - Labuda, Damian AU - Lari, Martina AU - Lazar, Catalin AU - Leppek, Maleen AU - Leshtakov, Krassimir AU - Vetro, Domenico Lo AU - Los, Dženi AU - Lozanov, Ivaylo AU - Malina, Maria AU - Martini, Fabio AU - McSweeney, Kath AU - Meller, Harald AU - Menđušić, Marko AU - Mirea, Pavel AU - Moiseyev, Vyacheslav AU - Petrova, Vanya AU - Price, T. Douglas AU - Simalcsik, Angela AU - Sineo, Luca AU - Šlaus, Mario AU - Slavchev, Vladimir AU - Stanev, Petar AU - Starović, Andrej AU - Szeniczey, Tamás AU - Talamo, Sahra AU - Teschler-Nicola, Maria AU - Thevenet, Corinne AU - Valchev, Ivan AU - Valentin, Frédérique AU - Vasilyev, Sergey AU - Veljanovska, Fanica AU - Venelinova, Svetlana AU - Veselovskaya, Elizaveta AU - Viola, Bence AU - Virag, Cristian AU - Zaninović, Joško AU - Zäuner, Steve AU - Stockhammer, Philipp W. AU - Catalano, Giulio AU - Krauß, Raiko AU - Caramelli, David AU - Zariņa, Gunita AU - Gaydarska, Bisserka AU - Lillie, Malcolm AU - Nikitin, Alexey G. AU - Potekhina, Inna AU - Papathanasiou, Anastasia AU - Borić, Dušan AU - Bonsall, Clive AU - Krause, Johannes AU - Pinhasi, Ron AU - Reich, David TI - The Genomic History Of Southeastern Europe AID - 10.1101/135616 DP - 2017 Jan 01 TA - bioRxiv PG - 135616 4099 - http://biorxiv.org/content/early/2017/09/19/135616.short 4100 - http://biorxiv.org/content/early/2017/09/19/135616.full AB - Farming was first introduced to southeastern Europe in the mid-7th millennium BCE – brought by migrants from Anatolia who settled in the region before spreading throughout Europe. To clarify the dynamics of the interaction between the first farmers and indigenous hunter-gatherers where they first met, we analyze genome-wide ancient DNA data from 223 individuals who lived in southeastern Europe and surrounding regions between 12,000 and 500 BCE. We document previously uncharacterized genetic structure, showing a West-East cline of ancestry in hunter-gatherers, and show that some Aegean farmers had ancestry from a different lineage than the northwestern Anatolian lineage that formed the overwhelming ancestry of other European farmers. We show that the first farmers of northern and western Europe passed through southeastern Europe with limited admixture with local hunter-gatherers, but that some groups mixed extensively, with relatively sex-balanced admixture compared to the male-biased hunter-gatherer admixture that prevailed later in the North and West. Southeastern Europe continued to be a nexus between East and West after farming arrived, with intermittent genetic contact from the Steppe up to 2,000 years before the migration that replaced much of northern Europe’s population.