RT Journal Article
SR Electronic
T1 An evidence-based network approach to recommending targeted cancer therapies
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 605261
DO 10.1101/605261
A1 Jayaram Kancherla
A1 Shruti Rao
A1 Krithika Bhuvaneshwar
A1 Rebecca B. Riggins
A1 Robert A. Beckman
A1 Subha Madhavan
A1 Héctor Corrada Bravo
A1 Simina M. Boca
YR 2019
UL http://biorxiv.org/content/early/2019/04/11/605261.abstract
AB In this work, we introduce CDGnet, an evidence-based network approach for recommending targeted cancer therapies, available as a user-friendly informatics tool. Our approach can be used to expand the range of options of targeted therapies for cancer patients who undergo molecular profiling. It considers biological pathway information specifically by looking at downstream targets of oncogenes and is personalized for individual patients via the user-inputted molecular alterations and cancer type. CDGnet integrates disparate sources of knowledge and provides results in a number of easily-accessible and usable forms, while separating targeted cancer therapies into categories in an evidence-based manner.