PT  - JOURNAL ARTICLE
AU  - Martin J. Dietz
AU  - Jørgen F. Nielsen
AU  - Andreas Roepstorff
AU  - Marta I. Garrido
TI  - Dysconnection of right parietal and frontal cortex in neglect syndrome
AID  - 10.1101/192583
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 192583
4099  - http://biorxiv.org/content/early/2017/09/22/192583.short
4100  - http://biorxiv.org/content/early/2017/09/22/192583.full
AB  - A lesion to the right hemisphere of the brain often leads to perceptual neglect of the left side of the sensorium. The fact that lesions to different cortical regions lead to the same symptoms points to neglect as a dysconnection syndrome that may result from the dysconnection of a distributed network, rather than a disruption of computation in any particular brain region. To test this hypothesis, we used Bayesian analysis of effective connectivity based on electroencephalographic recordings in patients with left-sided neglect after a right-hemisphere lesion. While age-matched healthy controls showed a contralateral increase in connection strength between parietal and frontal cortex with respect to the laterality of the stimuli, neglect patients showed a dysconnection between parietal and frontal cortex in the right hemisphere when stimuli appeared on their neglected side, but preserved connectivity in the left hemisphere when stimuli appeared on their right. Crucially, this parieto-frontal feedback connectivity was aggravated in patients with more severe symptoms. In contrast, patients and controls did not show differences in the local connectivity within regions. These findings suggest that the aetiology of neglect may lie in the dysconnection of a distributed network, rather than the disruption of any particular brain region.