RT Journal Article
SR Electronic
T1 Ultra-compliant carbon nanotube stretchable direct bladder interface
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 580902
DO 10.1101/580902
A1 Yan, Dongxiao
A1 Bruns, Tim M.
A1 Wu, Yuting
A1 Zimmerman, Lauren L.
A1 Stephan, Chris
A1 Cameron, Anne P.
A1 Yoon, Euisik
A1 Seymour, John P.
YR 2019
UL http://biorxiv.org/content/early/2019/04/13/580902.abstract
AB The bladder, stomach, intestines, heart, and lungs all move dynamically to achieve their purpose. A long-term implantable device that can attach onto an organ, sense its movement, and deliver current to modify the organ function would be useful in many therapeutic applications. The bladder, for example, is a smooth muscle organ that can suffer from incomplete contractions that result in urinary retention with patients requiring using catheterization. Those affected may benefit from a combination of strain sensor and electrical stimulator to better control bladder emptying. We describe the materials and design of such a device made from thin layer carbon nanotube (CNT) and Ecoflex 00-50 and demonstrate its function with in vivo feline bladders. During bench-top characterization, the resistive and capacitive sensors exhibited reliable output throughout 5,000 stretching cycles under physiology condition. In vivo measurement with piezoresistive device showed a high correlation between sensor resistance and volume. Stimulation driven from Pt-PDMS composite electrodes successfully induced bladder contraction. We present method for reliable connection and packaging of medical grade wire to the CNT device. This work is an important step toward the translation of low-durometer elastomers, stretchable CNT percolation and Pt-PDMS composite, which are ideal for large strain bioelectric applications to sense or modulate dynamic organ states.