PT  - JOURNAL ARTICLE
AU  - Ram, Yoav
AU  - Dellus-Gur, Eynat
AU  - Obolski, Uri
AU  - Bibi, Maayan
AU  - Berman, Judith
AU  - Hadany, Lilach
TI  - Predicting competition results from growth curves
AID  - 10.1101/022640
DP  - 2015 Jan 01
TA  - bioRxiv
PG  - 022640
4099  - http://biorxiv.org/content/early/2015/07/23/022640.short
4100  - http://biorxiv.org/content/early/2015/07/23/022640.full
AB  - Measuring relative fitness by pairwise competition experiments is laborious and expensive. Accordingly, many investigators estimate fitness from the maximum growth rate during exponential growth. However, maximum growth rates have been shown to be an unreliable measure of fitness as indicated by discrepancies between these parameters and the outcomes of pairwise competition experiments. Here we propose a new method that estimates relative fitness by predicting the results of competition experiments from single strain growth curves.