RT Journal Article
SR Electronic
T1 Long-term natural selection affects patterns of neutral divergence on the X chromosome more than the autosomes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 023234
DO 10.1101/023234
A1 Pooja Narang
A1 Melissa A. Wilson Sayres
YR 2015
UL http://biorxiv.org/content/early/2015/07/27/023234.abstract
AB Natural selection reduces neutral population genetic diversity near coding regions of the genome because recombination has not had time to unlink selected alleles from nearby neutral regions. For ten sub-species of great apes, including human, we show that long-term selection affects estimates of divergence on the X differently from the autosomes. Divergence increases with increasing distance from genes on both the X chromosome and autosomes, but increases faster on the X chromosome than autosomes, resulting in increasing ratios of X/A divergence in putatively neutral regions. Similarly, divergence is reduced more on the X chromosome in neutral regions near conserved regulatory elements than on the autosomes. Consequently estimates of male mutation bias, which rely on comparing neutral divergence between the X and autosomes, are twice as high in neutral regions near genes versus far from genes. Our results suggest filters for putatively neutral genomic regions differ between the X and autosomes.