PT - JOURNAL ARTICLE AU - O. Malaspinas AU - A. Turjman AU - D. Ribeiro de Sousa AU - G. Garcia-Cardena AU - M. Raes AU - P.-T. T. Nguyen AU - Y. Zhang AU - G. Courbebaisse AU - C. Lelubre AU - K. Zouaoui Boudjeltia AU - B. Chopard TI - A spatio-temporal model for spontaneous thrombus formation in cerebral aneurysms AID - 10.1101/023226 DP - 2015 Jan 01 TA - bioRxiv PG - 023226 4099 - http://biorxiv.org/content/early/2015/07/27/023226.short 4100 - http://biorxiv.org/content/early/2015/07/27/023226.full AB - We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based on in vitro experiments and clinical observations. We document that we can reproduce very well the shape and volume of patient specific thrombus segmented in giant aneurysms.