%0 Journal Article %A Sudipta Tung %A Abhishek Mishra %A Sutirth Dey %T Stabilizing the dynamics of laboratory populations of Drosophila melanogaster through upper and lower limiter controls %D 2015 %R 10.1101/023507 %J bioRxiv %P 023507 %X Although a large number of methods exist to control the dynamics of populations to a desired state, few of them have been empirically validated. This limits the scope of using these methods in real-life scenarios. To address this issue, we tested the efficacy of two well-known control methods in enhancing different kinds of stability in highly fluctuating, extinction-prone populations of Drosophila melanogaster. The Upper Limiter Control (ULC) method was able to reduce the fluctuations in population sizes as well as the extinction probability of the populations. On the negative side, it had no effect on the effective population size and required a large amount of effort. On the other hand, Lower Limiter Control (LLC) enhanced effective population size and reduced extinction probability at a relatively low amount of effort. However, its effects on population fluctuations were equivocal. We examined the population size distributions with and without the control methods, to derive biologically intuitive explanations for how these control methods work. We also show that biologically-realistic simulations, using a very general population dynamics model, are able to capture most of the trends of our data. This suggests that our results are likely to be generalizable to a wide range of scenarios. %U https://www.biorxiv.org/content/biorxiv/early/2015/07/31/023507.full.pdf