PT  - JOURNAL ARTICLE
AU  - Alexei V. Tkachenko
AU  - Sergei Maslov
TI  - Onset of natural selection in auto-catalytic heteropolymers
AID  - 10.1101/204826
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 204826
4099  - http://biorxiv.org/content/early/2017/10/17/204826.short
4100  - http://biorxiv.org/content/early/2017/10/17/204826.full
AB  - Reduction of information entropy along with ever-increasing complexity are among the key signatures of living matter. Understanding the onset of such behavior in early prebiotic world is essential for solving the problem of origins of life. To elucidate this transition, we study a theoretical model of information-storing heteropolymers capable of template-assisted ligation and subjected to cyclic non-equilibrium driving forces. We discover that this simple physical system undergoes a spontaneous reduction of the information entropy due to the competition of chains for constituent monomers. This natural-selection-like process ultimately results in the survival of a limited subset of polymer sequences. Importantly, the number of surviving sequences remains exponentially large, thus opening up the possibility of further increase in complexity due to Darwinian evolution. We also propose potential experimental implementations of our model using either biopolymers or artificial nano-structures.