RT Journal Article
SR Electronic
T1 Organizing principles of pulvino-cortical connectivity in humans
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 205039
DO 10.1101/205039
A1 Michael J. Arcaro
A1 Mark A. Pinsk
A1 Janice Chen
A1 Sabine Kastner
YR 2017
UL http://biorxiv.org/content/early/2017/10/18/205039.abstract
AB The pulvinar regulates information transmission to cortex and communication between cortical areas. The way the pulvinar interacts with cortex is governed by its intrinsic organization. Here, we show using fMRI that the human pulvinar is functionally heterogeneous, broadly separated into dorsal and ventral subdivisions based on characterization of response properties and functional connectivity with cortex. These differences mirrored the organization of the dorsal and ventral streams of visual cortex. The ventral subdivision of the pulvinar was functionally coupled with occipital and temporal cortex. The dorsal subdivision of the pulvinar was functionally coupled with frontal and parietal cortex. The dorsal subdivision was also coupled with the human-specific tool network and to the default mode network. The spatial organization of pulvino-cortical coupling reflected both the functional similarities and anatomical distances between cortical areas. Together, the human pulvinar appears to represent the entire visual system and the principles that govern its organization, though in a spatially compressed form.Author Contributions MA, MP, and JC collected data; MA and JC analyzed the data; MA, MP, JC, and SK wrote the paper.