PT  - JOURNAL ARTICLE
AU  - Ghislain Gillard
AU  - Ophélie Nicolle
AU  - Thibault Brugières
AU  - Sylvain Prigent
AU  - Mathieu Pinot
AU  - Grégoire Michaux
TI  - Coordinated morphogenesis through tension-induced planar polarity
AID  - 10.1101/207209
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 207209
4099  - http://biorxiv.org/content/early/2017/10/21/207209.short
4100  - http://biorxiv.org/content/early/2017/10/21/207209.full
AB  - Tissues from different developmental origins must interact to achieve coordinated morphogenesis at the level of a whole organism. C. elegans embryonic elongation is controlled by actomyosin dynamics which trigger cell shape changes in the epidermis and by muscle contractions, but how the two processes are coordinated is not known. We found that a tissue-wide tension generated by muscle contractions and relayed by tendon-like hemidesmosomes in the dorso-ventral epidermis is required to establish a planar polarity of the apical PAR module in the lateral epidermis. This planar polarized PAR module then controls actin planar organization, thus determining the orientation of cell shape changes and the elongation axis of the whole embryo. This trans-tissular mechanotransduction pathway thus contributes to coordinate the morphogenesis of three embryonic tissues.