TY - JOUR T1 - Gene expression in patient-derived neural progenitors provide insights into neurodevelopmental aspects of schizophrenia JF - bioRxiv DO - 10.1101/209197 SP - 209197 AU - Oleg V Evgrafov AU - Chris Armoskus AU - Bozena B Wrobel AU - Valeria N Spitsyna AU - Tade Souaiaia AU - Jennifer S. Herstein AU - Christopher P Walker AU - Joseph D Nguyen AU - Adrian Camarena AU - Jonathan R Weitz AU - Jae Mun ‘Hugo’ Kim AU - Edder Lopez Duarte AU - Kai Wang AU - George M Simpson AU - Janet L Sobell AU - Helena Medeiros AU - Michele T Pato AU - Carlos N Pato AU - James A Knowles Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/10/26/209197.abstract N2 - The PGC2 schizophrenia (SCZ) GWAS shows that variation in non-coding regions is responsible for most of the common variation heritability of the disease, suggesting risk variants alter gene expression. Therefore, comparing differences in gene expression between cases and controls may provide a direct approach for studying the etiology of SCZ. We studied transcriptome expression profiles of Cultured Neural progenitor cells derived from Olfactory Neuroepithelium lines (CNON) from 144 SCZ and 111 control individuals using RNA-Seq and identified 53 differentially expressed (DEX) genes (FDR<0.10).Most DEX genes are implicated in Wnt or Notch signaling, or the metabolism of serine/glutamine/asparagine. DEX genes show enrichment for overlap with significant variants from the SCZ GWAS, and for GO terms related to neurodevelopment: cell differentiation, migration, neurogenesis, and synapse assembly. Our findings show the utility of gene expression analysis of neural progenitors for deciphering molecular aberrations associated with, and potentially causing, schizophrenia. ER -