PT  - JOURNAL ARTICLE
AU  - Molly Schumer
AU  - Chenling Xu
AU  - Daniel L. Powell
AU  - Arun Durvasula
AU  - Laurits Skov
AU  - Chris Holland
AU  - Sriram Sankararaman
AU  - Peter Andolfatto
AU  - Gil G. Rosenthal
AU  - Molly Przeworski
TI  - Natural selection interacts with the local recombination rate to shape the evolution of hybrid genomes
AID  - 10.1101/212407
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 212407
4099  - http://biorxiv.org/content/early/2017/11/01/212407.short
4100  - http://biorxiv.org/content/early/2017/11/01/212407.full
AB  - While hybridization between species is increasingly appreciated to be a common occurrence, little is known about the forces that govern the subsequent evolution of hybrid genomes. We considered this question in three independent, naturally-occurring hybrid populations formed between swordtail fish species Xiphophorus birchmanni and X. malinche. To this end, we built a fine-scale genetic map and inferred patterns of local ancestry along the genomes of 690 individuals sampled from the three populations. In all three cases, we found hybrid ancestry to be more common in regions of high recombination and where there is linkage to fewer putative targets of selection. These same patterns are also apparent in a reanalysis of human-Neanderthal admixture. Our results lend support to models in which ancestry from the “minor” parental species persists only where it is rapidly uncoupled from alleles that are deleterious in hybrids, and show the retention of hybrid ancestry to be at least in part predictable from genomic features. Our analyses further indicate that in swordtail fish, the dominant source of selection on hybrids stems from deleterious combinations of epistatically-interacting alleles.One sentence summary The persistence of hybrid ancestry is predictable from local recombination rates, in three replicate hybrid populations as well as in humans.