RT Journal Article
SR Electronic
T1 Natural selection interacts with the local recombination rate to shape the evolution of hybrid genomes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 212407
DO 10.1101/212407
A1 Molly Schumer
A1 Chenling Xu
A1 Daniel L. Powell
A1 Arun Durvasula
A1 Laurits Skov
A1 Chris Holland
A1 Sriram Sankararaman
A1 Peter Andolfatto
A1 Gil G. Rosenthal
A1 Molly Przeworski
YR 2017
UL http://biorxiv.org/content/early/2017/11/01/212407.abstract
AB While hybridization between species is increasingly appreciated to be a common occurrence, little is known about the forces that govern the subsequent evolution of hybrid genomes. We considered this question in three independent, naturally-occurring hybrid populations formed between swordtail fish species Xiphophorus birchmanni and X. malinche. To this end, we built a fine-scale genetic map and inferred patterns of local ancestry along the genomes of 690 individuals sampled from the three populations. In all three cases, we found hybrid ancestry to be more common in regions of high recombination and where there is linkage to fewer putative targets of selection. These same patterns are also apparent in a reanalysis of human-Neanderthal admixture. Our results lend support to models in which ancestry from the “minor” parental species persists only where it is rapidly uncoupled from alleles that are deleterious in hybrids, and show the retention of hybrid ancestry to be at least in part predictable from genomic features. Our analyses further indicate that in swordtail fish, the dominant source of selection on hybrids stems from deleterious combinations of epistatically-interacting alleles.One sentence summary The persistence of hybrid ancestry is predictable from local recombination rates, in three replicate hybrid populations as well as in humans.