RT Journal Article
SR Electronic
T1 Running reduces firing but improves coding in rodent higher-order visual cortex
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 214007
DO 10.1101/214007
A1 Christensen, Amelia J.
A1 Pillow, Jonathan W.
YR 2017
UL http://biorxiv.org/content/early/2017/11/04/214007.abstract
AB Running profoundly alters stimulus-response properties in mouse primary visual cortex (V1), but its effects in higher-order visual cortex remain unknown. Here we systematically investigated how locomotion modulates visual responses across six visual areas and three cortical layers using a massive dataset from the Allen Brain Institute. Although running has been shown to increase firing in V1, we found that it suppressed firing in higher-order visual areas. Despite this reduction in gain, visual responses during running could be decoded more accurately than visual responses during stationary periods. We show that this effect was not attributable to changes in noise correlations, and propose that it instead arises from increased reliability of single neuron responses during running.