PT  - JOURNAL ARTICLE
AU  - Audrey Renson
AU  - Finn D. Schubert
AU  - Marc A. Bjurlin
TI  - Lack of insurance is associated with lower probability of diagnostic imaging use among US trauma patients: An instrumental variable analysis and simulation
AID  - 10.1101/215889
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 215889
4099  - http://biorxiv.org/content/early/2017/11/08/215889.short
4100  - http://biorxiv.org/content/early/2017/11/08/215889.full
AB  - Background Uninsured trauma patients have higher mortality than their insured counterparts. One possible reason is disparities in utilization of appropriate diagnostic imaging, including computed tomography (CT), X-ray, ultrasound (US), and magnetic resonance imaging (MRI). We examined the association between lack of insurance and use of diagnostic imaging.Methods Data come from the National Trauma Databank 2010-2015. Patients were determined uninsured if payment mode was self-pay or missing. The primary outcome was any diagnostic imaging procedure, and secondary outcomes included CT, X-ray, US, or MRI. Risk ratios (RRs) were adjusted for demographics, comorbidities, injury characteristics, facility characteristics. We also used the 2010 Patient Protection and Affordable Care Act as an instrumental variable (IV), with linear terms for year to account for annual trends in imaging use. Monte carlo simulations to test effect of hypothetical violations to IV assumptions of relevance, no direct effect, and no confounding.Results Of 4,373,554 patients, 953,281 (21.8%) were uninsured. After adjusting, uninsured patients had lower chance of any imaging (RR 0.98, 95% CI 0.98 to 0.98), x-ray (RR 0.99, 95% CI 0.99 to 1.00), and MRI (RR 0.82, 95% CI 0.81 to 0.83), and higher chance of ultrasound (RR 1.01, 95% CI 1.01 to 1.02). In IV analysis, uninsured status was associated with reduction in any imaging (RR 0.60, 95% CI 0.52 to 0.70), tomography (RR 0.52, 95% CI 0.44 to 0.62) ultrasound (RR 0.46, 95% CI 0.32 to 0.65), and MRI (RR 0.19, 95% CI 0.10 to 0.37) and increased likelihood of x-ray use (RR 1.74, 95% CI 1.31 to 2.32). Simulations indicated that a direct effect RD of −0.02 would be necessary to produce observed results under the null hypothesis.Discussion Our study suggests an association between insurance status and use of imaging that is unlikely to be driven by confounding or violations of IV assumptions. Mechanisms for this remain unclear, but could include unconscious provider bias or institutional financial constraints. Further research is warranted to elucidate mechanisms and assess whether differences in diagnostic imaging use mediate the association between insurance and mortality.