RT Journal Article
SR Electronic
T1 PopTargs: A database for studying population evolutionary genetics of human microRNA target sites
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 613372
DO 10.1101/613372
A1 Andrea Hatlen
A1 Mohab Helmy
A1 Antonio Marco
YR 2019
UL http://biorxiv.org/content/early/2019/04/18/613372.abstract
AB There is an increasing interest in the study of polymorphic variants at gene regulatory motifs, including microRNA target sites. Understanding the effects of selective forces at specific microRNA target sites, together with other factors like expression levels or evolutionary conservation, requires the joint study of multiple datasets. We have compiled information from multiple sources and compare it with predicted microRNA target sites to built a comprehensive database for the study of microRNA targets in human populations. PopTargs is a web-based tool that allows the easy extraction of multiple datasets and the joint analyses of them. The user can also compare the allele frequency spectrum between two groups of target sites, and conveniently produce plots. The database can be easily expanded as new data becomes available and the raw database as well as code for creating new custom made databases are available for downloading. We also describe a few illustrative examples. Poptargs is available at http://poptargs.essex.ac.uk