PT  - JOURNAL ARTICLE
AU  - Behrooz Darbani
AU  - Douglas B. Kell
AU  - Irina Borodina
TI  - Energetic Evolution of Cellular Transportomes
AID  - 10.1101/218396
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 218396
4099  - http://biorxiv.org/content/early/2017/11/12/218396.short
4100  - http://biorxiv.org/content/early/2017/11/12/218396.full
AB  - Transporter proteins mediate the translocation of substances across the membranes of living cells. We performed a genome-wide analysis of the compositional reshaping of cellular transporters (the transportome) across the kingdoms of bacteria, archaea, and eukarya. We show that the transportomes of eukaryotes evolved strongly towards a higher energetic efficiency, as ATP-dependent transporters diminished and secondary transporters and ion channels proliferated. This change has likely been important in the development of tissues performing energetically costly cellular functions. The transportome analysis also indicated seven bacterial species, including Neorickettsia risticii and Neorickettsia sennetsu, as likely origins of the mitochondrion in eukaryotes, due to the restricted presence therein of clear homologues of modern mitochondrial solute carriers.ADTATP-dependent transportersEUEenergy-usage efficiencyICion-channelsSTsecondary transporters