RT Journal Article
SR Electronic
T1 Energetic Evolution of Cellular Transportomes
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 218396
DO 10.1101/218396
A1 Behrooz Darbani
A1 Douglas B. Kell
A1 Irina Borodina
YR 2017
UL http://biorxiv.org/content/early/2017/11/12/218396.abstract
AB Transporter proteins mediate the translocation of substances across the membranes of living cells. We performed a genome-wide analysis of the compositional reshaping of cellular transporters (the transportome) across the kingdoms of bacteria, archaea, and eukarya. We show that the transportomes of eukaryotes evolved strongly towards a higher energetic efficiency, as ATP-dependent transporters diminished and secondary transporters and ion channels proliferated. This change has likely been important in the development of tissues performing energetically costly cellular functions. The transportome analysis also indicated seven bacterial species, including Neorickettsia risticii and Neorickettsia sennetsu, as likely origins of the mitochondrion in eukaryotes, due to the restricted presence therein of clear homologues of modern mitochondrial solute carriers.ADTATP-dependent transportersEUEenergy-usage efficiencyICion-channelsSTsecondary transporters