PT  - JOURNAL ARTICLE
AU  - Lingfei Wang
AU  - Tom Michoel
TI  - Whole-transcriptome causal network inference with genomic and transcriptomic data
AID  - 10.1101/213371
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 213371
4099  - http://biorxiv.org/content/early/2017/11/14/213371.short
4100  - http://biorxiv.org/content/early/2017/11/14/213371.full
AB  - Reconstruction of causal gene networks can distinguish regulators from targets and reduce false positives by integrating genetic variations. Its recent developments in speed and accuracy have enabled whole-transcriptome causal network inference on a personal computer. Here we demonstrate this technique with program Findr on 3,000 genes from the Geuvadis dataset. Subsequent analysis reveals major hub genes in the reconstructed network.