TY - JOUR T1 - Conversion between parallel and antiparallel β-sheets in wild-type and Iowa mutant fibrils JF - bioRxiv DO - 10.1101/220749 SP - 220749 AU - Wenhui Xi AU - Ulrich H.E. Hansmann Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/11/16/220749.abstract N2 - Using a variant of Hamilton-Replica-Exchange we study for wild type and Iowa mutant Aβ40 the conversion between fibrils with antiparallel β-sheets, and such with parallel β-sheets. We show that wild type and mutant form distinct salt bridges that in turn stabilize different fibril organizations. The conversion between the two fibril forms leads to the release of small aggregates that in the Iowa mutant may shift the equilibrium from fibrils to more toxic oligomers. ER -