RT Journal Article
SR Electronic
T1 Conversion between parallel and antiparallel β-sheets in wild-type and Iowa mutant fibrils
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 220749
DO 10.1101/220749
A1 Wenhui Xi
A1 Ulrich H.E. Hansmann
YR 2017
UL http://biorxiv.org/content/early/2017/11/16/220749.abstract
AB Using a variant of Hamilton-Replica-Exchange we study for wild type and Iowa mutant Aβ40 the conversion between fibrils with antiparallel β-sheets, and such with parallel β-sheets. We show that wild type and mutant form distinct salt bridges that in turn stabilize different fibril organizations. The conversion between the two fibril forms leads to the release of small aggregates that in the Iowa mutant may shift the equilibrium from fibrils to more toxic oligomers.