PT  - JOURNAL ARTICLE
AU  - Alexa Pichet Binette
AU  - Julie Gonneaud
AU  - Jacob W. Vogel
AU  - Renaud La Joie
AU  - Pedro Rosa-Neto
AU  - D. Louis Collins
AU  - Judes Poirier
AU  - John C.S. Breitner
AU  - Sylvia Villeneuve
AU  - Etienne Vachon-Presseau
AU  - Alzheimer’s Disease Neuroimaging Initiative
AU  - PREVENT-AD Research Group
TI  - Distinct changes in morphometric networks in aging versus Alzheimer’s disease dementia
AID  - 10.1101/615401
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 615401
4099  - http://biorxiv.org/content/early/2019/04/28/615401.short
4100  - http://biorxiv.org/content/early/2019/04/28/615401.full
AB  - Brain gray matter (GM) morphometric changes are prevalent in both aging and Alzheimers disease (AD), though disentangling these two processes has proved challenging. Using independent component analysis, we derived morphometric networks from a large, multi-cohort dataset, and investigated how GM volume within these networks differs in young adulthood, old adulthood, and AD. Aging and AD contributed additive effects on GM loss in nearly all networks, except frontal lobe networks, where GM reductions were more specific to aging. While no networks show GM loss highly specific to AD, a higher degree of variability in the whole-brain pattern of GM volume characterized AD only. Preservation of the whole-brain GM pattern in cognitively normal older adults was related to better cognition and lower risk of developing cognitive impairment. These results suggest both aging and AD involve widespread atrophy, but that cognitive impairment is uniquely associated with disruption of morphometric organization.