PT  - JOURNAL ARTICLE
AU  - Sarah L. Master
AU  - Maria K. Eckstein
AU  - Neta Gotlieb
AU  - Ronald Dahl
AU  - Linda Wilbrecht
AU  - Anne G.E. Collins
TI  - Distentangling the systems contributing to changes in learning during adolescence
AID  - 10.1101/622860
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 622860
4099  - http://biorxiv.org/content/early/2019/04/30/622860.short
4100  - http://biorxiv.org/content/early/2019/04/30/622860.full
AB  - Multiple neurocognitive systems contribute simultaneously to learning. For example, dopamine and basal ganglia (BG) systems are thought to support reinforcement learning (RL) by incrementally updating the value of choices, while the prefrontal cortex (PFC) contributes different computations, such as actively maintaining precise information in working memory (WM). It is commonly thought that WM and PFC show more protracted development than RL and BG systems, yet their contributions are rarely assessed in tandem. Here, we used a simple learning task to test how RL and WM contribute to changes in learning across adolescence. We tested 187 subjects ages 8 to 17 and 53 adults (25-30). Participants learned stimulus-action associations from feedback; the learning load was varied to be within or exceed WM capacity. Participants age 8-12 learned slower than participants age 13-17, and were more sensitive to load. We used computational modeling to estimate subjects’ use of WM and RL processes. Surprisingly, we found more robust changes in RL than WM during development. RL learning rate increased significantly with age across adolescence and WM parameters showed more subtle changes, many of them early in adolescence. These results underscore the importance of changes in RL processes for the developmental science of learning.Highlights- Subjects combine reinforcement learning (RL) and working memory (WM) to learn- Computational modeling shows RL learning rates grew with age during adolescence- When load was beyond WM capacity, weaker RL compensated less in younger adolescents- WM parameters showed subtler and more puberty-related changes- WM reliance, maintenance, and capacity had separable developmental trajectories- Underscores importance of RL processes in developmental changes in learning