PT  - JOURNAL ARTICLE
AU  - Gunn, B.G.
AU  - Cox, B.M.
AU  - Cox, C.D.
AU  - Le, A.A.
AU  - Inshishian, V.C.
AU  - Gall, C.M.
AU  - Lynch, G.
TI  - Acquisition of Temporal Order Involves a Reverberating Network in Hippocampal Field CA3
AID  - 10.1101/623025
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 623025
4099  - http://biorxiv.org/content/early/2019/04/30/623025.short
4100  - http://biorxiv.org/content/early/2019/04/30/623025.full
AB  - Here we report that hippocampal field CA3 maintains self-sustained activity for remarkable periods following a brief input and that this effect is extremely sensitive to minor perturbations. Using novel behavioral tests, that as with human episodic learning do not involve training or explicit rewards, we show that partial silencing of the network in mice blocks acquisition of temporal order, but not the identity or location, of odors. These results suggest a solution to the question of how hippocampus adds time to episodic memories.