TY - JOUR T1 - Structural abnormalities in thalamo-prefrontal tracks revealed by high angular resolution diffusion imaging predict working memory scores in concussed children JF - bioRxiv DO - 10.1101/624445 SP - 624445 AU - Guido I. Guberman AU - Jean-Christophe Houde AU - Alain Ptito AU - Isabelle Gagnon AU - Maxime Descoteaux Y1 - 2019/01/01 UR - http://biorxiv.org/content/early/2019/05/02/624445.abstract N2 - Because of their massive prevalence, wide-ranging sequelae, and insidious nature, concussions are a potentially devastating neurological condition, especially in children. Shearing forces transmitted across the brain during concussions often result in white matter damage. The neuropathological impact of concussions has been discerned from animal studies and includes inflammation, demyelination, and axonal loss. These pathologies can overlap during the subacute stage of recovery. However, due to the challenges of accurately modelling complex white matter structure, these neuropathologies have not yet been differentiated in children in vivo. In the present study, we leveraged recent advances in diffusion imaging modelling, tractography, and tractometry to better understand the neuropathology underlying working memory problems in concussion. Studying a sample of 16 concussed and 46 healthy youths, we used novel tractography methods to isolate 11 working memory tracks. Along these tracks, we measured fractional anisotropy, diffusivities, track volume, apparent fiber density, and free water fraction. In three tracks connecting the right thalamus to the right dorsolateral prefrontal cortex (DLPFC), we found microstructural differences suggestive of myelin alterations. In another track connecting the left anterior-cingulate cortex with the left DLPFC, we found microstructural changes suggestive of axonal loss. Structural differences and tractography reconstructions were reproduced using test-retest analyses. White matter structure in the three thalamo-prefrontal tracks, but not the cingulo-prefrontal track, appeared to play a key role in working memory function. The present results improve understanding of working memory neuropathology in concussions, which constitutes an important first step towards developing neuropathologically-informed biomarkers of concussion in children. ER -