RT Journal Article
SR Electronic
T1 Rapid evolution and biogeographic spread in a colorectal cancer
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 623850
DO 10.1101/623850
A1 Joao M Alves
A1 Sonia Prado-Lopez
A1 Jose Manuel Cameselle-Teijeiro
A1 David Posada
YR 2019
UL http://biorxiv.org/content/early/2019/05/02/623850.abstract
AB How and when tumoral clones start spreading to surrounding and distant tissues is currently unclear. Here, we leveraged a model-based evolutionary framework to investigate the demographic and biogeographic history of a colorectal cancer. Our analyses strongly support an early monoclonal metastatic colonization, followed by a rapid population expansion at both primary and secondary sites. Moreover, we infer a hematogenous metastatic spread seemingly under positive selection, plus the return of some tumoral cells from the liver back to the colon lymph nodes. This study illustrates how sophisticated techniques typical of organismal evolution can provide a detailed picture of the complex tumoral dynamics over time and space.