RT Journal Article
SR Electronic
T1 APOL1 is not expressed in proximal tubules and is not filtered
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 623918
DO 10.1101/623918
A1 Natalya A. Blessing
A1 Zhenzhen Wu
A1 Sethu Madhavan
A1 Myung K. Shin
A1 Maarten Hoek
A1 John R. Sedor
A1 John F. O’Toole
A1 Leslie A. Bruggeman
YR 2019
UL http://biorxiv.org/content/early/2019/05/02/623918.abstract
AB The kidney expression pattern of APOL1 was examined using both protein and mRNA in situ methods on APOL1 bacterial artificial chromosome transgenic mice, with and without proteinuria. APOL1 was detected in podocytes and endothelial cells of the kidney, but was not expressed in tubular epithelia, nor was plasma APOL1 protein filtered and reabsorbed by the proximal tubule. APOL1 expression in podocytes and endothelia should remain the focus for mechanistic studies of APOL1-mediated pathogenesis.