RT Journal Article
SR Electronic
T1 Quantitative relationships for radiation induced chromosome instability: data analysis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 224006
DO 10.1101/224006
A1 Y.A. Eidelman
A1 S.V. Slanina
A1 V.S. Pyatenko
A1 I.K. Khvostunov
A1 S.G. Andreev
YR 2017
UL http://biorxiv.org/content/early/2017/11/24/224006.abstract
AB The experimental observations demonstrate that different cell lines reveal various shape of dynamic curves for radiation-induced chromosomal instability (RICI). We analyzed our own and published data on RICI for three cell lines, CHO-K1, V79 and TK6, on the basis of the mechanistic RICI model. We demonstrate that all three dynamic curves can be successfully described by the proposed model with partially cell line specific parameters.