%0 Journal Article %A Bahar Moezzi %A Louise M. Lavrencic %A Mitchell R. Goldsworthy %A Scott Coussens %A Hannah A.D. Keage %T Associations between EEG functional brain connectivity and a cognitive reserve proxy in healthy older adults %D 2019 %R 10.1101/625608 %J bioRxiv %P 625608 %X Cognitive reserve is a concept that explains individual differences in vulnerability to cognitive impairment due to age and dementia-related brain changes. Mechanisms underlying the cognitive reserve effect are poorly understood. We investigated associations between a comprehensive cognitive reserve proxy (Lifetime Experiences Questionnaire/LEQ) and functional connectivity of the prefrontal cortex across the whole scalp, covarying for the level of current cognitive functioning (Addenbrookes Cognitive Examination Revised/ACE-R), using multiblock parallel and orthogonalized partial least squares regression. EEG data were collected from 34 healthy older adults (63 to 83 years) in eyes-open and eyes-closed resting-states, and during 0-back and 1-back tasks. Functional connectivity was estimated using imaginary coherence in the theta and alpha frequency bands, as these bands have been heavily implicated in cognitive ageing, attention and executive function. We found three clusters of electrodes where the absolute values of the regression coefficient were above threshold when covarying for ACE-R: (1) a cluster approximating the right frontocentral region during the eyes-open condition in the theta band with seed electrodes approximating the left prefrontal cortex with positive associations of medium effect size; (2) a cluster approximating the right parietotemporal region during the 0-back task in the theta band with seed electrodes approximating the right prefrontal cortex with negative associations of medium to large effect sizes; and (3) a cluster approximating the occipitoparietal region in the eyes-closed condition in the alpha band with seed electrodes approximating the left prefrontal cortex with negative associations of medium effect size. These relationships between a cognitive reserve proxy and functional connectivity, within key networks and frequency bands associated with attention and executive function, may reflect greater neural capacity and efficiency. %U https://www.biorxiv.org/content/biorxiv/early/2019/05/03/625608.full.pdf