RT Journal Article
SR Electronic
T1 Laminar-specific cortical dynamics in human visual and sensorimotor cortices
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 226274
DO 10.1101/226274
A1 James J Bonaiuto
A1 Sofie S Meyer
A1 Simon Little
A1 Holly Rossiter
A1 Martina F Callaghan
A1 Fred Dick
A1 Gareth R Barnes
A1 Sven Bestmann
YR 2017
UL http://biorxiv.org/content/early/2017/11/28/226274.abstract
AB Lower frequency, feedback, activity in the alpha and beta range is thought to predominantly originate from infragranular cortical layers, whereas feedforward signals in the gamma range stem largely from supragranular layers. Distinct anatomical and spectral channels may therefore play specialized roles in communication within hierarchical cortical networks; however, empirical evidence for this organization in humans is limited. We leverage high precision MEG to test this proposal, directly and non-invasively, in human participants during visually guided actions. Visual alpha activity mapped onto deep cortical laminae, whereas visual gamma activity predominantly arose from superficial laminae. This laminar-specificity was echoed in sensorimotor beta and gamma activity. Visual gamma activity scaled with task demands in a way compatible with feedforward signaling. For sensorimotor activity, we observed a more complex relationship with feedback and feedforward processes. Distinct frequency channels thus operate in a laminar-specific manner, but with dissociable functional roles across sensory and motor cortices.