PT  - JOURNAL ARTICLE
AU  - Goldsborough, Peter
AU  - Pawlowski, Nick
AU  - Caicedo, Juan C
AU  - Singh, Shantanu
AU  - Carpenter, Anne E
TI  - CytoGAN: Generative Modeling of Cell Images
AID  - 10.1101/227645
DP  - 2017 Jan 01
TA  - bioRxiv
PG  - 227645
4099  - http://biorxiv.org/content/early/2017/12/02/227645.short
4100  - http://biorxiv.org/content/early/2017/12/02/227645.full
AB  - We explore the application of Generative Adversarial Networks to the domain of morphological profiling of human cultured cells imaged by fluorescence microscopy. When evaluated for their ability to group cell images responding to treatment by chemicals of known classes, we find that adversarially learned representations are superior to autoencoder-based approaches. While currently inferior to classical computer vision and transfer learning, the adversarial framework enables useful visualization of the variation of cellular images due to their generative capabilities.