RT Journal Article SR Electronic T1 Miniring approach for high-throughput drug screenings in 3D tumor models JF bioRxiv FD Cold Spring Harbor Laboratory SP 138412 DO 10.1101/138412 A1 Nhan Phan A1 Bobby Tofig A1 Jin Huang A1 Sanaz Memarzadeh A1 Robert Damoiseaux A1 Alice Soragni YR 2017 UL http://biorxiv.org/content/early/2017/12/06/138412.abstract AB There is increasing interest in developing 3D tumor organoid models for drug development and personalized medicine approaches. While tumor organoids are in principle amenable to high-throughput drug screenings, progress has been hampered by technical constraints and extensive manipulations required by current approaches. Here, we introduce a miniaturized, fully automatable, flexible high-throughput method using a simplified geometry to establish 3D organoids from cell lines and primary tumors and robustly assay drug responses.