RT Journal Article
SR Electronic
T1 Assessment of patient-specific efficacy of chemo- and targeted-therapies: a micropharmacology approach
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 236653
DO 10.1101/236653
A1 Aleksandra Karolak
A1 Branton Huffstutler
A1 Zain Khan
A1 Katarzyna A. Rejniak
YR 2019
UL http://biorxiv.org/content/early/2019/05/06/236653.abstract
AB Both targeted and standard chemotherapy drugs are subject to various intratumoral barriers that impede their effectiveness. The tortuous vasculature, dense and fibrous extracellular matrix, irregular cellular architecture, and nonuniform expression of cell membrane receptors hinder drug molecule transport and perturb its cellular uptake. In addition, tumor microenvironments undergo dynamic spatio-temporal changes during tumor progression and treatment, which can also obstruct drug efficacy. To examine these aspects of drug delivery on a cell-to-tissue scale (single-cell pharmacology), we developed the microPKPD models and coupled them with patient-specific data to test personalized treatments.