RT Journal Article
SR Electronic
T1 Multi-resolution localization of causal variants across the genome
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 631390
DO 10.1101/631390
A1 Matteo Sesia
A1 Eugene Katsevich
A1 Stephen Bates
A1 Emmanuel Candès
A1 Chiara Sabatti
YR 2019
UL http://biorxiv.org/content/early/2019/05/08/631390.abstract
AB We present KnockoffZoom, a flexible method for the genetic mapping of complex traits at multiple resolutions. KnockoffZoom localizes causal variants precisely and provably controls the false discovery rate using artificial genotypes as negative controls. Our method is equally valid for quantitative and binary phenotypes, making no assumptions about their genetic architectures. Instead, we rely on well-established genetic models of linkage disequilibrium. We demonstrate that our method can detect more associations than mixed effects models and achieve fine-mapping precision, at comparable computational cost. Lastly, we apply KnockoffZoom to data from 350k subjects in the UK Biobank and report many new findings.