TY - JOUR T1 - Self-limiting population genetic control with sex-linked genome editors JF - bioRxiv DO - 10.1101/236489 SP - 236489 AU - Austin Burt AU - Anne Deredec Y1 - 2017/01/01 UR - http://biorxiv.org/content/early/2017/12/19/236489.abstract N2 - In male heterogametic species the Y chromosome is transmitted solely from fathers to sons, and is selected for based only on its impacts on male fitness. This fact can be exploited to develop efficient pest control strategies that use Y-linked editors to disrupt the fitness of female descendants. In simple “strategic” population models we show that Y-linked editors can be substantially more efficient than other self-limiting strategies and, while not as efficient as gene drive approaches, are expected to have less impact on non-target populations with which there is some gene flow. Efficiency can be further augmented by simultaneously releasing an autosomal X-shredder construct, in either the same or different males. Y-linked editors may be attractive option to consider when efficient control of a species is desired in some locales but not others. ER -