PT  - JOURNAL ARTICLE
AU  - AE Hernan
AU  - JM Mahoney
AU  - W Curry
AU  - S Mawe
AU  - RC Scott
TI  - Distributed dynamic coding for spatial working memory in hippocampal-prefrontal networks
AID  - 10.1101/630673
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 630673
4099  - http://biorxiv.org/content/early/2019/05/10/630673.short
4100  - http://biorxiv.org/content/early/2019/05/10/630673.full
AB  - Spatial working memory (SWM) is a central cognitive process during which the hippocampus and prefrontal cortex (PFC) encode and maintain spatial information for subsequent decision-making. This occurs in the context of ongoing computations relating to spatial position, recall of long-term memory, attention, amongst many others. To establish how intermittently presented information is integrated with ongoing computations we recorded single units, in both hippocampus and PFC, in control rats and those with a brain malformation during performance of a SWM task. Neurons that encode intermittent task parameters are also well-modulated in time and incorporated into a functional network across regions. Our results implicate a model in which ongoing oscillatory coordination among neurons in the hippocampal-PFC network defines a functional network that is poised to receive sensory inputs that are then integrated and multiplexed as working memory. These dynamics are systematically altered in disease and may provide potential targets for stimulation-based therapies.