RT Journal Article
SR Electronic
T1 Precise tuning of cortical contractility regulates cell shape during cytokinesis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 635615
DO 10.1101/635615
A1 Nilay Taneja
A1 Matthew R. Bersi
A1 Sophie Baillargeon
A1 Aidan M. Fenix
A1 James A. Cooper
A1 Ryoma Ohi
A1 Vivian Gama
A1 W. David Merryman
A1 Dylan T. Burnette
YR 2019
UL http://biorxiv.org/content/early/2019/05/13/635615.abstract
AB The mechanical properties of the cellular cortex regulate shape changes during cell division, cell migration and tissue morphogenesis. During cell division, contractile force generated by the molecular motor myosin II (MII) at the equatorial cortex drives cleavage furrow ingression. Cleavage furrow ingression in turn increases stresses at the polar cortex, where contractility must be regulated to maintain cell shape during cytokinesis. How polar cortex contractility controls cell shape is poorly understood. We show a balance between MII paralogs allows a fine-tuning of cortex tension at the polar cortex to maintain cell shape during cytokinesis, with MIIA driving cleavage furrow ingression and bleb formation, and MIIB serving as a stabilizing motor and mediating completion of cytokinesis. As the majority of non-muscle contractile systems are cortical, this tuning mechanism will likely be applicable to numerous processes driven by MII contractility.