RT Journal Article
SR Electronic
T1 Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 247353
DO 10.1101/247353
A1 Coleman, Jonathan R.I.
A1 Peyrot, Wouter J.
A1 Purves, Kirstin L.
A1 Davis, Katrina A.S.
A1 Rayner, Christopher
A1 Choi, Shing Wan
A1 Hübel, Christopher
A1 Gaspar, Héléna A.
A1 Kan, Carol
A1 Van der Auwera, Sandra
A1 Adams, Mark James
A1 Lyall, Donald M.
A1 Choi, Karmel W.
A1 ,
A1 Dunn, Erin C.
A1 Vassos, Evangelos
A1 Danese, Andrea
A1 Maughan, Barbara
A1 Grabe, Hans J.
A1 Lewis, Cathryn M.
A1 O’Reilly, Paul F.
A1 McIntosh, Andrew M.
A1 Smith, Daniel J.
A1 Wray, Naomi R.
A1 Hotopf, Matthew
A1 Eley, Thalia C.
A1 Breen, Gerome
YR 2019
UL http://biorxiv.org/content/early/2019/05/13/247353.abstract
AB Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD between individuals reporting and not reporting trauma exposure (final sample size range: 24,094-92,957). The SNP-based heritability of MDD was greater in participants reporting trauma exposure (24%) than in individuals not reporting trauma exposure (12%), taking into account the strong, positive genetic correlation observed between MDD and reported trauma exposure. The genetic correlation between MDD and waist circumference was only significant in individuals reporting trauma exposure (rg = 0.24, p = 1.8×10-7 versus rg = −0.05, p = 0.39 in individuals not reporting trauma exposure, difference p = 2.3×10-4). Our results suggest that the genetic contribution to MDD is greater when additional risk factors are present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.