RT Journal Article
SR Electronic
T1 Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 247353
DO 10.1101/247353
A1 Jonathan R.I. Coleman
A1 Wouter J. Peyrot
A1 Kirstin L. Purves
A1 Katrina A.S. Davis
A1 Christopher Rayner
A1 Shing Wan Choi
A1 Christopher Hübel
A1 Héléna A. Gaspar
A1 Carol Kan
A1 Sandra Van der Auwera
A1 Mark James Adams
A1 Donald M. Lyall
A1 Karmel W. Choi
A1 Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
A1 Erin C. Dunn
A1 Evangelos Vassos
A1 Andrea Danese
A1 Barbara Maughan
A1 Hans J. Grabe
A1 Cathryn M. Lewis
A1 Paul F. O’Reilly
A1 Andrew M. McIntosh
A1 Daniel J. Smith
A1 Naomi R. Wray
A1 Matthew Hotopf
A1 Thalia C. Eley
A1 Gerome Breen
YR 2019
UL http://biorxiv.org/content/early/2019/05/13/247353.abstract
AB Depression is more frequent among individuals exposed to traumatic events. Both trauma exposure and depression are heritable. However, the relationship between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD between individuals reporting and not reporting trauma exposure (final sample size range: 24,094-92,957). The SNP-based heritability of MDD was greater in participants reporting trauma exposure (24%) than in individuals not reporting trauma exposure (12%), taking into account the strong, positive genetic correlation observed between MDD and reported trauma exposure. The genetic correlation between MDD and waist circumference was only significant in individuals reporting trauma exposure (rg = 0.24, p = 1.8×10-7 versus rg = −0.05, p = 0.39 in individuals not reporting trauma exposure, difference p = 2.3×10-4). Our results suggest that the genetic contribution to MDD is greater when additional risk factors are present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.